About the event
This one-day workshop will describe some of the fundamental theory underpinning polygenic risk score (PRS) analyses; provide hands-on practical sessions illustrating both basic and more complex PRS analyses; and illustrate the application of PRS using examples from published and ongoing research. We will use our PRSice software in computer practicals but will also describe how the same kind of analyses can be performed with alternatives (eg. LDpred). Topics covered will include: QC; pruning/clumping; the sample overlap problem; estimating pseudo-R2; ascertainment; multi-ethnic PRS; over-fitting; shrinkage methods; PRS for G*G/G*E and the potential for PRS to contribute to clinical prediction and Personalised Medicine
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King's College London
King's College London is one of the top 10 UK universities in the world and among the oldest in England. King's vision is to make the world a better place, building on our history of pioneering research that has advanced and shaped modern life. King's is dedicated to the advancement of knowledge learning & understanding in the service of society.
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